Clinical Presentation and Management of Sweet Syndrome: A Case Report
While the syndrome can be idiopathic, drug-induced cases are more common in women. Medications frequently associated with the development of Sweet syndrome include contraceptives, antiepileptics, antibiotics, antihypertensives, vaccines, and colony-stimulating factors. However, as this case highlights, other medications may potentially act as triggers.
The gold standard for initial treatment is the administration of oral corticosteroids. Patients typically show a rapid response, with systemic discomfort and pain subsiding within the first few hours of therapy and skin lesions clearing in less than a week. In this instance, the sudden emergence of lesions required a rigorous differential diagnosis to rule out conditions such as urticaria, contact dermatitis, toxicoderma, and cutaneous lupus. The integration of clinical history, laboratory findings, and the conclusive histopathological results from the biopsy allowed the medical team to reach a definitive diagnosis of Sweet syndrome, ensuring the patient received the correct targeted treatment.
